Ziff Davis Enterprise has a white paper about online backup, SaaS backup, cloud backup or whatever you want to call it. I've used Mozy for quite a while and think it's really convenient. My Outlook PST files, Visual Studio projects, AutoCAD drawings, everything is backuped and I don't need to think about closing Outlook or AutoCAD to have the backup working in the background several times a day.
IT departments typically configure user PCs so all work files are stored on network drives. But most users circumvent this approach, storing files on their hard drives. Additionally, laptops users often work outside the office and offline, synchronizing only sporadically and keeping their current work on the local drive. As a result, data on local drives doesn’t get backed up.
I know by experience how true that is with users having the bad habit to save all their CAD work on the desktop instead of in the correct location on the network for example.
You can find the white paper here after registering.
If you want to just try Mozy you can do it for free as long as you don't need to backup more than 2 GB. If you need more there are affordable plans for unlimited space.